Central poststroke pain: a review of pathophysiology and treatment. Central post-stroke pain: clinical characteristics, pathophysiology, and management. Scrambler therapy is a safe and feasible intervention that improves neuropathic pain in patients with neuromyelitis optica spectrum disorder: a Phase II randomized controlled trial. Mealy MA, Kozachik SL, Cook LJ PhD et al. Case report: scrambler therapy for treatment-resistant central neuropathic pain in a patient with transverse myelitis. Mealy MA, Newsome SD, Kozachik SL, Levy M, Smith TJ. Central poststroke pain: an abstruse outcome. Inside the scrambler therapy, a noninvasive treatment of chronic neuropathic and cancer pain: from the gate control theory to the active principle of information. Treatment of human immunodeficiency virus-related peripheral neuropathy with scrambler therapy: a case report. Smith TJ, Auwaerter P, Knowlton A, Saylor D, McArthur J. Predictive factors associated with success and failure for Calmare (scrambler) therapy: a multi-center analysis. Moon JY, Kurihara C, Beckles JP, Williams KE, Jamison DE, Cohen SP. Scrambler therapy may relieve chronic neuropathic pain more effectively than guideline-based drug management: results of a pilot, randomized, controlled trial. Marineo G, Iorno V, Gandini C, Moschini V, Smith TJ. Scrambler therapy for the treatment of chronic central pain: a case report. D'Amato SJ, Mealy MA, Erdek MA, Kozachik S, Smith TJ. Deep brain stimulation for the treatment of various chronic pain syndromes. Rasche D, Rinaldi PC, Young RF, Tronnier VM. Management of central poststroke pain: systematic review of randomized controlled trials. Pharmacological management of central post-stroke pain: a practical guide. Central pain: diagnosis and treatment strategies. Central poststroke pain: current diagnosis and treatment. Deep brain stimulation for the treatment of Dejerine–Roussy Syndrome. Further multi-institutional trials are warranted for this rare syndrome. Conclusion: Scrambler therapy appeared to reverse 6 years of disabling pain safely and economically, and continues to be effective.
Months later, he resumed normal activity and is off all his pain medications. Results: His allodynia and hyperalgesia resolved within 10 min, and his pain score fell to almost zero after 30 min. Methods: A 56-year-old man received multiple daily then monthly treatments with electrode pairs placed just above the area of distal pain. We used scrambler therapy to treat a patient with 6 years of disabling Déjerine–Roussy syndrome pain.
SCRAMBLER THERAPY SKIN
Scrambler therapy is a form of neuromodulation that uses external skin electrodes to send a ‘non-pain’ signal to the brain, with some success in difficult-to-treat syndromes such as neuromyelitis optica spectrum disorder. Aim: Déjerine–Roussy syndrome or central thalamic pain can be devastating, and treatment with drugs and even deep brain stimulation can be unsatisfactory.